Examples

The app contains a series of example cases that can be used for pedagogical purposes. You may access and load them using the Examples menu on the navigation bar. In the following sections you can find a more detailed description of each one.

📄️ 1) Constant relative risk

A simple case to showcase the relative risk mode and the importance of accounting for age of onset.

📄️ 2) X-linked inheritance

A case example demonstrating how to perform an X-linked analysis.

📄️ 3) Two phenotypes

An example with two phenotypes in a consanguineous family.

📄️ 4) Breast cancer and BRCA1

An example from Belman et al. (2020) showing a complex model with age-dependent relative risks.

note

The results of all these cases assume a rare variant frequency in the population of 0.001 (0.1%).